Brian G. Lawhorn, Ph.D.

Affiliations: 
2004 Cornell University, Ithaca, NY, United States 
Area:
Barton Professor of Chemistry
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"Brian Lawhorn"
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Tadhg P. Begley grad student 2004 Cornell
 (Studies on the biosynthesis of the thiamin pyrimidine in bacteria.)
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Publications

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Lawhorn BG, Philp J, Zhao Y, et al. (2015) Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K). Journal of Medicinal Chemistry. 58: 7431-48
Vagnozzi RJ, Gatto GJ, Kallander LS, et al. (2013) Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Science Translational Medicine. 5: 207ra141
Swingle MR, Amable L, Lawhorn BG, et al. (2009) Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 331: 45-53
Lawhorn BG, Boga SB, Wolkenberg SE, et al. (2006) Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32
Lawhorn BG, Boga SB, Wolkenberg SE, et al. (2006) Total synthesis of cytostatin Heterocycles. 70: 65-70
Lawhorn BG, Mehl RA, Begley TP. (2004) Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. Organic & Biomolecular Chemistry. 2: 2538-46
Lawhorn BG, Gerdes SY, Begley TP. (2004) A genetic screen for the identification of thiamin metabolic genes. The Journal of Biological Chemistry. 279: 43555-9
Ge Y, Lawhorn BG, ElNaggar M, et al. (2003) Detection of four oxidation sites in viral prolyl-4-hydroxylase by top-down mass spectrometry. Protein Science : a Publication of the Protein Society. 12: 2320-6
Ge Y, Lawhorn BG, ElNaggar M, et al. (2002) Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry. Journal of the American Chemical Society. 124: 672-8
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