Eugen F. Mesaros, Ph.D.

Affiliations: 
2003 Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
organoiron chemistry, organocatalysts
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"Eugen Mesaros"
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Anthony J. Pearson grad student 2003 Case Western
 (Stereocontrolled functionalization of lateral carbon-carbon double bonds in acyclic pi-allylmolybdenum complexes.)
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Publications

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Ott GR, Cheng M, Learn KS, et al. (2016) Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK). Journal of Medicinal Chemistry
Mesaros EF, Angeles TS, Albom MS, et al. (2015) Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase. Bioorganic & Medicinal Chemistry Letters. 25: 1047-52
Mesaros EF, Ott GR, Dorsey BD. (2014) Anaplastic lymphoma kinase inhibitors as anticancer therapeutics: a patent review. Expert Opinion On Therapeutic Patents. 24: 417-42
Dugan BJ, Gingrich DE, Mesaros EF, et al. (2012) A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779. Journal of Medicinal Chemistry. 55: 5243-54
Mesaros EF, Thieu TV, Wells GJ, et al. (2012) Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitors. Journal of Medicinal Chemistry. 55: 115-25
Wells-Knecht KJ, Ott GR, Cheng M, et al. (2011) 2,7-Disubstituted-pyrrolotriazine kinase inhibitors with an unusually high degree of reactive metabolite formation. Chemical Research in Toxicology. 24: 1994-2003
Ott GR, Wells GJ, Thieu TV, et al. (2011) 2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activity. Journal of Medicinal Chemistry. 54: 6328-41
Zificsak CA, Theroff JP, Aimone LD, et al. (2011) Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 3877-80
Mesaros EF, Burke JP, Parrish JD, et al. (2011) Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models. Bioorganic & Medicinal Chemistry Letters. 21: 463-6
Smith AB, Xiong H, Charnley AK, et al. (2010) Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones. Organic Letters. 12: 2994-7
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