Brian P. Callahan, Ph.D.
Affiliations: | 2005 | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
Kinetics of Enzymatic ReactionsGoogle:
"Brian Callahan"Mean distance: 8.65 | S | N | B | C | P |
Parents
Sign in to add mentor| Richard V. Wolfenden | grad student | 2005 | UNC Chapel Hill | |
| (Mechanism of (bio)alkylation and decarboxylation in water, and mechanistic inhibitors of orotidine 5'-phosphate decarboxylase.) | ||||
Children
Sign in to add trainee| Andrew George Wagner | grad student | Binghamton University (SUNY) | |
| Daniel Ciulla | grad student | 2018-2022 | SUNY Binghamton (Neurotree) |
BETA: Related publications
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Publications
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| Ciulla DA, Xu Z, Pezzullo JL, et al. (2023) Paracatalytic induction: Subverting specificity in hedgehog protein autoprocessing with small molecules. Methods in Enzymology. 685: 1-41 |
| Callahan BP, Xu Z. (2023) There's more to enzyme antagonism than inhibition. Bioorganic & Medicinal Chemistry. 82: 117231 |
| Ciulla DA, Dranchak P, Pezzullo JL, et al. (2022) A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators. The Journal of Biological Chemistry. 102705 |
| Wagner AG, Stagnitta RT, Xu Z, et al. (2021) Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition. Biochemistry |
| Callahan BP, Ciulla DA, Wagner AG, et al. (2020) Specificity Distorted: Chemical Induction of Biological Paracatalysis. Biochemistry |
| Smith CJ, Wagner AG, Stagnitta RT, et al. (2020) Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis. Biochemistry |
| Zhao J, Ciulla DA, Xie J, et al. (2019) General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing. Journal of the American Chemical Society |
| Zhang X, Xu Z, Moumin DS, et al. (2019) Protein-Nucleic Acid Conjugation with Sterol Linkers Using Hedgehog Autoprocessing. Bioconjugate Chemistry |
| Ciulla DA, Wagner AG, Liu X, et al. (2019) Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism. Chemical Communications (Cambridge, England) |
| Ciulla D, Jorgensen M, Giner JL, et al. (2017) Chemical bypass of general base catalysis in hedgehog protein cholesterolysis using a hyper-nucleophilic substrate. Journal of the American Chemical Society |