Alexander V. Tobias, Ph.D.

Affiliations: 
2006 California Institute of Technology, Pasadena, CA 
Area:
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuels
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"Alexander Tobias"
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Frances H. Arnold grad student 2006 Caltech
 (Directed evolution of biosynthetic pathways to carotenoids with unnatural carbon backbones.)
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Publications

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Meyer AJ, Saaem I, Silverman A, et al. (2019) Organism engineering for the bioproduction of the triaminotrinitrobenzene (TATB) precursor phloroglucinol (PG). Acs Synthetic Biology
Furubayashi M, Ikezumi M, Takaichi S, et al. (2015) A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes. Nature Communications. 6: 7534
Tobias AV, Arnold FH. (2006) Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways. Biochimica Et Biophysica Acta. 1761: 235-46
Umeno D, Tobias AV, Arnold FH. (2005) Diversifying carotenoid biosynthetic pathways by directed evolution. Microbiology and Molecular Biology Reviews : Mmbr. 69: 51-78
Tobias AV, Joern JM. (2003) Solid-phase screening using digital image analysis. Methods in Molecular Biology (Clifton, N.J.). 230: 109-15
Umeno D, Tobias AV, Arnold FH. (2002) Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway. Journal of Bacteriology. 184: 6690-9
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