Clara L. Kielkopf, Ph.D.

Affiliations: 
2000 California Institute of Technology, Pasadena, CA 
Area:
Protein Structure and Energetics; X-ray Crystallography
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"Clara Kielkopf"
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SNBCP

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Douglas C. Rees grad student 2000 Caltech
 (Structural basis of DNA recognition by synthetic ligands.)
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Publications

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Chatrikhi R, Feeney CF, Pulvino MJ, et al. (2021) A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chemical Biology
Maji D, Glasser E, Henderson S, et al. (2020) Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. The Journal of Biological Chemistry. 295: 17148-17157
Maji D, Glasser E, Henderson S, et al. (2020) Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. The Journal of Biological Chemistry
Talkish J, Igel H, Hunter O, et al. (2019) Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction. Rna (New York, N.Y.)
Loerch S, Leach JR, Horner SW, et al. (2018) The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. The Journal of Biological Chemistry
Glasser E, Agrawal A, Jenkins JL, et al. (2017) Cancer-associated mutations mapped on high resolution structures of the U2AF2 RNA recognition motifs. Biochemistry
Jenkins JL, Kielkopf CL. (2017) Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures. Trends in Genetics : Tig
Agrawal AA, Salsi E, Chatrikhi R, et al. (2016) An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nature Communications. 7: 10950
Loerch S, Kielkopf CL. (2015) Dividing and Conquering the Family of RNA Recognition Motifs: A Representative Case Based on hnRNP L. Journal of Molecular Biology. 427: 2997-3000
Okeyo-Owuor T, White BS, Chatrikhi R, et al. (2015) U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing. Leukemia. 29: 909-17
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