Andrew C. Mercer, Ph.D.

Affiliations: 
2008 Chemistry University of California, San Diego, La Jolla, CA 
Area:
Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering
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"Andrew Mercer"
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SNBCP

Parents

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Michael D. Burkart grad student 2008 UCSD
 (Co-opting CoA biosynthesis for the in vivo modification of carrier proteins.)
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Publications

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Johari YB, Mercer AC, Liu Y, et al. (2021) Design of synthetic promoters for controlled expression of therapeutic genes in retinal pigment epithelial cells. Biotechnology and Bioengineering
Kaelber JT, Yost SA, Webber KA, et al. (2020) Structure of the AAVhu.37 capsid by cryoelectron microscopy. Acta Crystallographica. Section F, Structural Biology Communications. 76: 58-64
Gaj T, Sirk SJ, Tingle RD, et al. (2014) Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign. Journal of the American Chemical Society. 136: 5047-56
Sirk SJ, Gaj T, Jonsson A, et al. (2014) Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants. Nucleic Acids Research. 42: 4755-66
Mercer AC, Gaj T, Sirk SJ, et al. (2014) Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors. Acs Synthetic Biology. 3: 723-30
Lamb BM, Mercer AC, Barbas CF. (2013) Directed evolution of the TALE N-terminal domain for recognition of all 5' bases. Nucleic Acids Research. 41: 9779-85
Gaj T, Mercer AC, Sirk SJ, et al. (2013) A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Research. 41: 3937-46
Mercer AC, Gaj T, Fuller RP, et al. (2012) Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Research. 40: 11163-72
Gersbach CA, Gaj T, Gordley RM, et al. (2011) Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Research. 39: 7868-78
Gaj T, Mercer AC, Gersbach CA, et al. (2011) Structure-guided reprogramming of serine recombinase DNA sequence specificity. Proceedings of the National Academy of Sciences of the United States of America. 108: 498-503
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