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Andrew C. Mercer, Ph.D.

Affiliations: 
2008 Chemistry University of California, San Diego, La Jolla, CA 
Area:
Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering
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"Andrew Mercer"
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Parents

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Michael D. Burkart grad student 2008 UCSD
 (Co-opting CoA biosynthesis for the in vivo modification of carrier proteins.)

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Publications

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Kaelber JT, Yost SA, Webber KA, et al. (2020) Structure of the AAVhu.37 capsid by cryoelectron microscopy. Acta Crystallographica. Section F, Structural Biology Communications. 76: 58-64
Gaj T, Sirk SJ, Tingle RD, et al. (2014) Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign. Journal of the American Chemical Society. 136: 5047-56
Sirk SJ, Gaj T, Jonsson A, et al. (2014) Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants. Nucleic Acids Research. 42: 4755-66
Mercer AC, Gaj T, Sirk SJ, et al. (2014) Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors. Acs Synthetic Biology. 3: 723-30
Lamb BM, Mercer AC, Barbas CF. (2013) Directed evolution of the TALE N-terminal domain for recognition of all 5' bases. Nucleic Acids Research. 41: 9779-85
Gaj T, Mercer AC, Sirk SJ, et al. (2013) A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Research. 41: 3937-46
Mercer AC, Gaj T, Fuller RP, et al. (2012) Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Research. 40: 11163-72
Gersbach CA, Gaj T, Gordley RM, et al. (2011) Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Research. 39: 7868-78
Gaj T, Mercer AC, Gersbach CA, et al. (2011) Structure-guided reprogramming of serine recombinase DNA sequence specificity. Proceedings of the National Academy of Sciences of the United States of America. 108: 498-503
Mercer AC, Meier JL, Torpey JW, et al. (2009) In vivo modification of native carrier protein domains. Chembiochem : a European Journal of Chemical Biology. 10: 1091-100
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