Timothy L. Foley, Ph.D.

Affiliations: 
2010 Chemistry University of California, San Diego, La Jolla, CA 
Area:
Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering
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"Timothy Foley"
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Michael D. Burkart grad student 2010 UCSD
 (Manipulating posttranslational modification in natural product biosynthesis.)
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Publications

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Coussens NP, Sittampalam GS, Guha R, et al. (2018) The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science
Foley TL, Dorjsuren D, Dexheimer TS, et al. (2016) A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays. Journal of Biomolecular Screening
Cavalier MC, Pierce AD, Wilder PT, et al. (2014) Covalent small molecule inhibitors of Ca(2+)-bound S100B. Biochemistry. 53: 6628-40
Foley TL, Rai G, Yasgar A, et al. (2014) 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth. Journal of Medicinal Chemistry. 57: 1063-78
Kosa NM, Foley TL, Burkart MD. (2014) Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors. The Journal of Antibiotics. 67: 113-20
Foley TL, Simeonov A. (2012) Targeting iron assimilation to develop new antibacterials Expert Opinion On Drug Discovery. 7: 831-847
Yu WL, Guizzunti G, Foley TL, et al. (2010) An optimized immunoaffinity fluorescent method for natural product target elucidation. Journal of Natural Products. 73: 1659-66
Foley TL, Yasgar A, Garcia CJ, et al. (2010) Preparation of FRET reporters to support chemical probe development. Organic & Biomolecular Chemistry. 8: 4601-6
Yasgar A, Foley TL, Jadhav A, et al. (2010) A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase. Molecular Biosystems. 6: 365-75
Foley TL, Young BS, Burkart MD. (2009) Phosphopantetheinyl transferase inhibition and secondary metabolism. The Febs Journal. 276: 7134-45
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