Sheryl R. Bowley, Ph.D.

Affiliations: 
2008 Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Role of Fibrinogen in Cardiovascular Diseases
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Parents

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Susan T. Lord grad student 2008 UNC Chapel Hill
 (Insights from structure-function studies of variant fibrinogen.)
Bruce Furie post-doc 2013-2017 Harvard - BIDMC
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Publications

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Bowley SR, Fang C, Merrill-Skoloff G, et al. (2017) Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation. Nature Communications. 8: 14151
Lin L, Gopal S, Sharda A, et al. (2015) Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain. The Journal of Biological Chemistry. 290: 23543-52
Kennedy DR, Nag PP, Galinski CN, et al. (2013) Development Of Second Generation Thiol Isomerase Inhibitors To Prevent Thrombus Formation Blood. 122: 926-926
Jasuja R, Passam FH, Kennedy DR, et al. (2012) Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. The Journal of Clinical Investigation. 122: 2104-13
Bowley SR, Okumura N, Lord ST. (2009) Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions. Biochemistry. 48: 8656-63
Bowley SR, Lord ST. (2009) Fibrinogen variant BbetaD432A has normal polymerization but does not bind knob "B". Blood. 113: 4425-30
Bowley SR, Merenbloom BK, Okumura N, et al. (2008) Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic. Biochemistry. 47: 8607-13
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