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John A. Zuris, Ph.D.

Affiliations: 
2012 Chemistry University of California, San Diego, La Jolla, CA 
Area:
protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies
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"John Zuris"
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Patricia A. Jennings grad student 2012 UCSD
 (Unraveling the Biological Role and Emerging Capabilities of a Novel Class of Type 2 Diabetes Drug Targets.)

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Publications

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Wang M, Zuris JA, Meng F, et al. (2016) Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. Proceedings of the National Academy of Sciences of the United States of America
Davis KM, Pattanayak V, Thompson DB, et al. (2015) Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nature Chemical Biology. 11: 316-8
Zuris JA, Thompson DB, Shu Y, et al. (2015) Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature Biotechnology. 33: 73-80
Tamir S, Rotem-Bamberger S, Katz C, et al. (2014) Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. Proceedings of the National Academy of Sciences of the United States of America. 111: 5177-82
Tamir S, Zuris JA, Agranat L, et al. (2013) Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs. Plos One. 8: e61202
Baxter EL, Zuris JA, Wang C, et al. (2013) Allosteric control in a metalloprotein dramatically alters function. Proceedings of the National Academy of Sciences of the United States of America. 110: 948-53
Nechushtai R, Conlan AR, Harir Y, et al. (2012) Characterization of Arabidopsis NEET reveals an ancient role for NEET proteins in iron metabolism. The Plant Cell. 24: 2139-54
Zuris JA, Ali SS, Yeh H, et al. (2012) NADPH inhibits [2Fe-2S] cluster protein transfer from diabetes drug target MitoNEET to an apo-acceptor protein. The Journal of Biological Chemistry. 287: 11649-55
Zuris JA, Ali SS, Yeh H, et al. (2012) Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Blocks Transfer of [2Fe-2S] Clusters from MitoNEET to an Apo-Acceptor Protein Biophysical Journal. 102: 459a
Conlan AR, Zuris JA, Paddock ML, et al. (2012) The Interaction Between Cisd2 and Bcl Proteins at a Non-BH3 Domain Binding Site Biophysical Journal. 102: 258a-259a
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