Akos Nemecz, Ph.D.
Affiliations: | 2011 | Chemistry | University of California, San Diego, La Jolla, CA |
Area:
Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kineticsGoogle:
"Akos Nemecz"Mean distance: 8.6 | S | N | B | C | P |
Parents
Sign in to add mentor| Elizabeth A. Komives | grad student | 2011 | UCSD | |
| (Towards an understanding of human alpha-7 nicotinic acetylcholine receptor selectivity: the creation and characterization of a soluble ligand binding domain template.) | ||||
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Publications
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| Li Q, Nemecz Á, Aymé G, et al. (2023) Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor. Cellular and Molecular Life Sciences : Cmls. 80: 164 |
| Van Renterghem C, Nemecz Á, Delarue-Cochin S, et al. (2023) Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket. The Journal of Physiology |
| Hu H, Nemecz Á, Van Renterghem C, et al. (2018) Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation. Proceedings of the National Academy of Sciences of the United States of America |
| Nemecz Á, Prevost MS, Menny A, et al. (2016) Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels. Neuron. 90: 452-70 |
| Sauguet L, Shahsavar A, Poitevin F, et al. (2014) Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proceedings of the National Academy of Sciences of the United States of America. 111: 966-71 |
| Yamauchi JG, Gomez K, Grimster N, et al. (2012) Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates. Molecular Pharmacology. 82: 687-99 |
| Grimster NP, Stump B, Fotsing JR, et al. (2012) Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. Journal of the American Chemical Society. 134: 6732-40 |
| Nemecz A, Taylor P. (2011) Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses. The Journal of Biological Chemistry. 286: 42555-65 |
| Yamauchi JG, Nemecz Á, Nguyen QT, et al. (2011) Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. Plos One. 6: e16519 |