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Timothy D. Silverstein, Ph.D.

Affiliations: 
2011 Biophysics, Structural Biology, and Biomathematics Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Protein-nucleic acid interactions: studied by X-ray crystallography and other biophysical methods
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"Timothy Silverstein"
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Parents

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Aneel K. Aggarwal grad student 2011 Mount Sinai School of Medicine
 (Structural Studies of Y-family DNA Polymerases Eta and Kappa: Replication Through Ultraviolet-Induced and Oxidative DNA Damage.)

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Publications

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Terakawa T, Redding S, Silverstein TD, et al. (2017) Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor. Proceedings of the National Academy of Sciences of the United States of America
Silverstein TD, Gibb B, Greene EC. (2014) Visualizing protein movement on DNA at the single-molecule level using DNA curtains. Dna Repair. 20: 94-109
Gibb B, Silverstein TD, Finkelstein IJ, et al. (2012) Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions. Analytical Chemistry. 84: 7607-12
Ummat A, Rechkoblit O, Jain R, et al. (2012) Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy. Nature Structural & Molecular Biology. 19: 628-32
Ummat A, Silverstein TD, Jain R, et al. (2012) Human DNA polymerase η is pre-aligned for dNTP binding and catalysis. Journal of Molecular Biology. 415: 627-34
Vasquez-Del Carpio R, Silverstein TD, Lone S, et al. (2011) Role of human DNA polymerase κ in extension opposite from a cis-syn thymine dimer. Journal of Molecular Biology. 408: 252-61
Silverstein TD, Jain R, Johnson RE, et al. (2010) Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase η. Structure (London, England : 1993). 18: 1463-70
Silverstein TD, Johnson RE, Jain R, et al. (2010) Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature. 465: 1039-43
Vasquez-Del Carpio R, Silverstein TD, Lone S, et al. (2009) Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion. Plos One. 4: e5766
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