Nisha Rajagopal, Ph.D.

2013 Bioinformatics and System Biology University of California, San Diego, La Jolla, CA 
Inference of gene regulatory networks and determination of protein specificity
"Nisha Rajagopal"
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Wei Wang grad student 2013 UCSD
 (Navigating the Human Epigenome through Random Forests.)
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Hu S, Marineau JJ, Rajagopal N, et al. (2019) Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. Cancer Research
Hu S, Marineau J, Hamman K, et al. (2019) Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo Cancer Research. 79: 4421-4421
Ke N, Johannessen L, Rajagopal N, et al. (2019) Abstract 4409: Prospective identification of RB pathway alterations predict response to SY-1365, a selective CDK7 inhibitor, in a panel of high-grade serous ovarian cancer (HGSOC) patient derived xenograft (PDX) models Cancer Research. 79: 4409-4409
Johannessen LH, Hu S, Ke N, et al. (2019) Abstract C091: Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clinical development in multiple solid tumor indications Molecular Cancer Therapeutics. 18
Rajagopal N, Hodgson G, Hu S, et al. (2018) Abstract P1-09-08:BCL2L1(BCL-XL) expression and MYC super-enhancer positivity predict sensitivity to the covalent CDK7 inhibitor SY-1365 in triple negative breast cancer (TNBC) cell lines Cancer Research. 78
Konstantinopoulos PA, Hodgson G, Rajagopal N, et al. (2018) Abstract 1525: SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo Cancer Research. 78: 1525-1525
Hu S, Ke N, Ren Y, et al. (2017) Abstract 1151: SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors Cancer Research. 77: 1151-1151
Hashimoto TB, Sherwood R, Kang DD, et al. (2016) A synergistic DNA logic predicts genome-wide chromatin accessibility. Genome Research
Schultz MD, He Y, Whitaker JW, et al. (2015) Corrigendum: Human body epigenome maps reveal noncanonical DNA methylation variation. Nature
Schultz MD, He Y, Whitaker JW, et al. (2015) Human body epigenome maps reveal noncanonical DNA methylation variation. Nature. 523: 212-6
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