Christina C. Capule, Ph.D.

Affiliations: 
2012 Chemistry University of California, San Diego, La Jolla, CA 
Area:
Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology
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"Christina Capule"
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Jerry Yang grad student 2012 UCSD
 (The Design, Synthesis, and Evaluation of Compounds that Bind to Alzheimer's-related and HIV-1-related Amyloids.)
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Publications

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Lee JY, Nam JH, Nam Y, et al. (2018) The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD. Journal of Neuroinflammation. 15: 286
Cifelli JL, Capule C, Yang J. (2018) Non-covalent, electrostatic interactions induce positively cooperative binding of small molecules to Alzheimer's and Parkinson's disease-related amyloids. Acs Chemical Neuroscience
Lee NJ, Song JM, Cho HJ, et al. (2015) Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-ras dependent pathway. Biochimica Et Biophysica Acta
Megill A, Lee T, DiBattista AM, et al. (2013) A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9306-18
Capule CC, Yang J. (2012) Enzyme-linked immunosorbent assay-based method to quantify the association of small molecules with aggregated amyloid peptides. Analytical Chemistry. 84: 1786-91
Capule CC, Brown C, Olsen JS, et al. (2012) Oligovalent amyloid-binding agents reduce SEVI-mediated enhancement of HIV-1 infection. Journal of the American Chemical Society. 134: 905-8
Chang WM, Dakanali M, Capule CC, et al. (2011) ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. Acs Chemical Neuroscience. 2: 249-255
Olsen JS, Brown C, Capule CC, et al. (2010) Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection. The Journal of Biological Chemistry. 285: 35488-96
Sutharsan J, Dakanali M, Capule CC, et al. (2010) Rational design of amyloid binding agents based on the molecular rotor motif. Chemmedchem. 5: 56-60
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