Peter A. Doucette, Ph.D.
Affiliations: | 2004 | University of California, Los Angeles, Los Angeles, CA |
Area:
Copper-Zinc Superoxide Dismutase and ALS, Redox Balance, Oxidative Stress, and Metal Ion Metabolism in Eukaryotic CellsGoogle:
"Peter Doucette"Mean distance: 8.81 | S | N | B | C | P |
Parents
Sign in to add mentorJoan Selverstone Valentine | grad student | 2004 | UCLA | |
(Biophysical studies of human copper-zinc superoxide dismutase and mutants associated with the neurodegenerative disease amyotrophic lateral sclerosis.) |
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Publications
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Seetharaman SV, Winkler DD, Taylor AB, et al. (2010) Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R. Biochemistry. 49: 5714-25 |
Oztug Durer ZA, Cohlberg JA, Dinh P, et al. (2009) Loss of metal ions, disulfide reduction and mutations related to familial ALS promote formation of amyloid-like aggregates from superoxide dismutase. Plos One. 4: e5004 |
Cao X, Antonyuk SV, Seetharaman SV, et al. (2008) Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 283: 16169-77 |
Potter SZ, Zhu H, Shaw BF, et al. (2007) Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein. Journal of the American Chemical Society. 129: 4575-83 |
Strange RW, Antonyuk SV, Hough MA, et al. (2006) Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes. Journal of Molecular Biology. 356: 1152-62 |
Rodriguez JA, Shaw BF, Durazo A, et al. (2005) Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 10516-21 |
Valentine JS, Doucette PA, Zittin Potter S. (2005) Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Annual Review of Biochemistry. 74: 563-93 |
Antonyuk S, Elam JS, Hough MA, et al. (2005) Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg. Protein Science : a Publication of the Protein Society. 14: 1201-13 |
Doucette PA, Whitson LJ, Cao X, et al. (2004) Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability. The Journal of Biological Chemistry. 279: 54558-66 |
Hough MA, Grossmann JG, Antonyuk SV, et al. (2004) Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants. Proceedings of the National Academy of Sciences of the United States of America. 101: 5976-81 |