Eric L. Wise, Ph.D.

Affiliations: 
2003 University of Wisconsin, Madison, Madison, WI 
Area:
Structural Biology
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"Eric Wise"
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Ivan Rayment grad student 2003 UW Madison
 (Investigations into the structural and functional relationships among divergently related enzymes.)
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Publications

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Wise EL, Yew WS, Akana J, et al. (2005) Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: structural basis for catalytic promiscuity in wild-type and designed mutants of 3-keto-L-gulonate 6-phosphate decarboxylase. Biochemistry. 44: 1816-23
Yew WS, Akana J, Wise EL, et al. (2005) Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase. Biochemistry. 44: 1807-15
Wise EL, Akana J, Gerlt JA, et al. (2004) Structure of D-ribulose 5-phosphate 3-epimerase from Synechocystis to 1.6 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 60: 1687-90
Wise EL, Yew WS, Gerlt JA, et al. (2004) Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: crystallographic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase. Biochemistry. 43: 6438-46
Yew WS, Wise EL, Rayment I, et al. (2004) Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: mechanistic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase. Biochemistry. 43: 6427-37
Wise EL, Rayment I. (2004) Understanding the importance of protein structure to nature's routes for divergent evolution in TIM barrel enzymes. Accounts of Chemical Research. 37: 149-58
Wise EL, Yew WS, Gerlt JA, et al. (2003) Structural evidence for a 1,2-enediolate intermediate in the reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase, a member of the orotidine 5'-monophosphate decarboxylase suprafamily. Biochemistry. 42: 12133-42
Wise EL, Graham DE, White RH, et al. (2003) The structural determination of phosphosulfolactate synthase from Methanococcus jannaschii at 1.7-A resolution: an enolase that is not an enolase. The Journal of Biological Chemistry. 278: 45858-63
Wise E, Yew WS, Babbitt PC, et al. (2002) Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase. Biochemistry. 41: 3861-9
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