Jeremiah J. Frye, Ph.D.

2010 University of Wisconsin, Madison, Madison, WI 
Structural Biology
"Jeremiah Frye"
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Ivan Rayment grad student 2010 UW Madison
 (Novel approaches to stabilizing and crystallizing coiled-coil containing proteins.)
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Brown NG, VanderLinden R, Watson ER, et al. (2015) RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 5272-9
Yamaguchi M, Yu S, Qiao R, et al. (2015) Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. Journal of Molecular Biology. 427: 1748-64
Brown NG, Watson ER, Weissmann F, et al. (2014) Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Molecular Cell. 56: 246-60
Frye JJ, Brown NG, Petzold G, et al. (2013) Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nature Structural & Molecular Biology. 20: 827-35
Klenchin VA, Frye JJ, Jones MH, et al. (2011) Structure-function analysis of the C-terminal domain of CNM67, a core component of the Saccharomyces cerevisiae spindle pole body. The Journal of Biological Chemistry. 286: 18240-50
Frye J, Klenchin VA, Rayment I. (2010) Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition. Biochemistry. 49: 4908-20
Frye JJ, Klenchin VA, Bagshaw CR, et al. (2010) Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236. Biochemistry. 49: 4897-907
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