Brian A. Kelch, Ph.D.
Affiliations: | 2007 | University of California, San Francisco, San Francisco, CA | |
| 2012- | University of Massachusetts Medical School, Worcester, MA, United States |
Area:
Structure, function, and folding of proteins, chromosomes, and centrosomesWebsite:
https://profiles.umassmed.edu/display/132262Google:
"Brian Kelch"Bio:
https://www.umassmed.edu/kelchlab/
https://www.eurekalert.org/pub_releases/2014-06/uomm-ums062414.php
Mean distance: 9.27
Parents
Sign in to add mentor| David A. Agard | grad student | 2007 | UCSF | |
| (Identifying the structural determinants of extreme folding and unfolding barriers.) | ||||
| John Kuriyan | post-doc | UC Berkeley | ||
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Publications
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| Landeck JT, Pajak J, Norman EK, et al. (2024) Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication. The Journal of Biological Chemistry. 107166 |
| Landeck JT, Pajak J, Norman EK, et al. (2023) Differences in clamp loader mechanism between bacteria and eukaryotes. Biorxiv : the Preprint Server For Biology |
| Magrino J, Munford V, Martins DJ, et al. (2023) A thermosensitive PCNA allele underlies an Ataxia Telangiectasia-like disorder. The Journal of Biological Chemistry. 104656 |
| Li H, O'Donnell M, Kelch B. (2022) Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200154 |
| Özden C, Sloutsky R, Mitsugi T, et al. (2022) CaMKII binds both substrates and activators at the active site. Cell Reports. 40: 111064 |
| Liu X, Gaubitz C, Pajak J, et al. (2022) A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA. Elife. 11 |
| Gaubitz C, Liu X, Pajak J, et al. (2022) Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. Elife. 11 |
| Pajak J, Dill E, Reyes-Aldrete E, et al. (2021) Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. Nucleic Acids Research |
| Pajak J, Atz R, Hilbert BJ, et al. (2021) Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Gaubitz C, Liu X, Magrino J, et al. (2020) Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch. Proceedings of the National Academy of Sciences of the United States of America |