Brian A. Kelch, Ph.D.

Affiliations: 
2007 University of California, San Francisco, San Francisco, CA 
 2012- University of Massachusetts Medical School, Worcester, MA, United States 
Area:
Structure, function, and folding of proteins, chromosomes, and centrosomes
Website:
https://profiles.umassmed.edu/display/132262
Google:
"Brian Kelch"
Bio:

https://www.umassmed.edu/kelchlab/
https://www.eurekalert.org/pub_releases/2014-06/uomm-ums062414.php

Mean distance: 9.27
 
SNBCP

Parents

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David A. Agard grad student 2007 UCSF
 (Identifying the structural determinants of extreme folding and unfolding barriers.)
John Kuriyan post-doc UC Berkeley
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Publications

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Landeck JT, Pajak J, Norman EK, et al. (2024) Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication. The Journal of Biological Chemistry. 107166
Landeck JT, Pajak J, Norman EK, et al. (2023) Differences in clamp loader mechanism between bacteria and eukaryotes. Biorxiv : the Preprint Server For Biology
Magrino J, Munford V, Martins DJ, et al. (2023) A thermosensitive PCNA allele underlies an Ataxia Telangiectasia-like disorder. The Journal of Biological Chemistry. 104656
Li H, O'Donnell M, Kelch B. (2022) Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200154
Özden C, Sloutsky R, Mitsugi T, et al. (2022) CaMKII binds both substrates and activators at the active site. Cell Reports. 40: 111064
Liu X, Gaubitz C, Pajak J, et al. (2022) A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA. Elife. 11
Gaubitz C, Liu X, Pajak J, et al. (2022) Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. Elife. 11
Pajak J, Dill E, Reyes-Aldrete E, et al. (2021) Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. Nucleic Acids Research
Pajak J, Atz R, Hilbert BJ, et al. (2021) Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. Proceedings of the National Academy of Sciences of the United States of America. 118
Gaubitz C, Liu X, Magrino J, et al. (2020) Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch. Proceedings of the National Academy of Sciences of the United States of America
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