Andrew P. VanDemark, Ph.D.

Affiliations: 
2002 Johns Hopkins University, Baltimore, MD 
Area:
lysine ubiquitination and acetylation, using x-ray crystallography, together with biochemical, biophysical and genetic analysis
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"Andrew VanDemark"
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Cynthia Wolberger grad student 2002 Johns Hopkins
 (Structural and biochemical studies of the Mms2 /Ubc13 ubiquitin conjugating enzyme complex from yeast.)
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Publications

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Roland BP, Richards KR, Hrizo SL, et al. (2019) Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo. Biochimica Et Biophysica Acta. Molecular Basis of Disease
Zalewski JK, Mo JH, Heber S, et al. (2016) Structure of the Shroom-Rho kinase complex reveals a binding interface with monomeric Shroom that regulates cell morphology and stimulates kinase activity. The Journal of Biological Chemistry
Roland BP, Zeccola AM, Larsen SB, et al. (2016) Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics. Plos Genetics. 12: e1005941
Gaines WA, Godin SK, Kabbinavar FF, et al. (2015) Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52. Nature Communications. 6: 7834
Roland BP, Amrich CG, Kammerer CJ, et al. (2015) Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency. Biochimica Et Biophysica Acta. 1852: 61-9
Singh S, Rockenbach K, Dedrick RM, et al. (2014) Cross-talk between diverse serine integrases. Journal of Molecular Biology. 426: 318-31
Singh S, Plaks JG, Homa NJ, et al. (2014) The structure of Xis reveals the basis for filament formation and insight into DNA bending within a mycobacteriophage intasome. Journal of Molecular Biology. 426: 412-22
Mohan S, Das D, Bauer RJ, et al. (2013) Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology. Plos One. 8: e81075
Wier AD, Mayekar MK, Héroux A, et al. (2013) Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proceedings of the National Academy of Sciences of the United States of America. 110: 17290-5
Roland BP, Stuchul KA, Larsen SB, et al. (2013) Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity. Journal of Cell Science. 126: 3151-8
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