Michael D. Purdy, Ph.D.

Affiliations: 
2002 University of Virginia, Charlottesville, VA 
Area:
Structural biology of membrane proteins
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"Michael Purdy"
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Michael C. Wiener grad student 2002 UVA
 (Crystallization of a bacterial ClC chloride channel and thiol -reactive lanthanide chelates for phasing X -ray diffraction data.)
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Publications

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Khan AK, Jagielnicki M, Bennett BC, et al. (2021) Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs. Structure (London, England : 1993)
Khan AK, Jagielnicki M, McIntire WE, et al. (2020) A Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels. Cell Reports. 31: 107482
Mukherjee S, Erramilli SK, Ammirati M, et al. (2020) Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nature Communications. 11: 1598
Purdy MD, Bennett BC, McIntire WE, et al. (2014) Function and dynamics of macromolecular complexes explored by integrative structural and computational biology. Current Opinion in Structural Biology. 27: 138-48
Bennett B, Purdy M, Baker K, et al. (2013) X-Ray Structure of the Cx26 Gap Junction Channel and Comparison with the Cryo-EM Structure of Cx43 Biophysical Journal. 104: 42a-43a
Vergis JM, Purdy MD, Wiener MC. (2010) A high-throughput differential filtration assay to screen and select detergents for membrane proteins. Analytical Biochemistry. 407: 1-11
Cuello LG, Jogini V, Cortes DM, et al. (2010) Design and characterization of a constitutively open KcsA. Febs Letters. 584: 1133-8
Shultis DD, Purdy MD, Banchs CN, et al. (2006) Crystallization and preliminary X-ray crystallographic analysis of the Escherichia coli outer membrane cobalamin transporter BtuB in complex with the carboxy-terminal domain of TonB. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 638-41
Shultis DD, Purdy MD, Banchs CN, et al. (2006) Outer membrane active transport: structure of the BtuB:TonB complex. Science (New York, N.Y.). 312: 1396-9
Oleksy A, Barton H, Devedjiev Y, et al. (2004) Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF Acta Crystallographica Section D: Biological Crystallography. 60: 740-742
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