Kathleen M. Frey, Ph.D.

Affiliations: 
2015- Pharmaceutical Sciences Long Island University Pharmacy 
Area:
Medicinal Chemistry, X-Ray crystallography, Structural biology, Molecular modeling, Structure-based drug design
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"Kathleen Frey"
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Parents

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Amy Christine Anderson grad student 2011 University of Connecticut
 (Towards the Understanding of Resistance Mutations in Dihydrofolate Reductase from Methicillin-resistant Staphylococcus aureus.)
Karen S. Anderson post-doc Yale School of Medicine
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Publications

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Sasaki T, Gannam ZTK, Kudalkar SN, et al. (2019) Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters
Frey KM. (2015) Structure-enhanced methods in the development of non-nucleoside inhibitors targeting HIV reverse transcriptase variants. Future Microbiology
Gray WT, Frey KM, Laskey SB, et al. (2015) Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. Acs Medicinal Chemistry Letters. 6: 1075-9
Lee WG, Frey KM, Gallardo-Macias R, et al. (2015) Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorganic & Medicinal Chemistry Letters. 25: 4824-7
Frey KM, Puleo DE, Spasov KA, et al. (2015) Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants. Journal of Medicinal Chemistry. 58: 2737-45
Sohl CD, Ryan MR, Luo B, et al. (2015) Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. Acs Chemical Biology. 10: 1319-29
Reeve SM, Gainza P, Frey KM, et al. (2015) Protein design algorithms predict viable resistance to an experimental antifolate. Proceedings of the National Academy of Sciences of the United States of America. 112: 749-54
Sohl CD, Ryan M, Luo B, et al. (2015) Abstract 2436: Understanding the molecular mechanism of targeted kinase inhibitor resistance mediated by the FGFR1 gatekeeper mutation Cancer Research. 75: 2436-2436
Sohl CD, Ryan MR, Luo B, et al. (2015) Illuminating the molecular ,mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: The Achilles' heel of targeted therapy Acs Chemical Biology. 10: 1319-1329
Lee WG, Frey KM, Gallardo-Macias R, et al. (2015) Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase Bioorganic and Medicinal Chemistry Letters
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