Magdalena Dorywalska, Ph.D.

Affiliations: 
2007 Stanford University, Palo Alto, CA 
Area:
the role of RNA in cellular processes and disease
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"Magdalena Dorywalska"
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Joseph Puglisi grad student 2007 Stanford
 (Conformational dynamics of protein synthesis.)
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Publications

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Dorywalska M, Dushin R, Moine L, et al. (2016) Molecular basis of valine-citrulline-PABC linker instability in site-specific ADCs and its mitigation by linker design. Molecular Cancer Therapeutics
Dorywalska M, Strop P, Melton-Witt JA, et al. (2015) Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy. Plos One. 10: e0132282
Strop P, Delaria K, Foletti D, et al. (2015) Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading. Nature Biotechnology. 33: 694-6
Dorywalska M, Strop P, Melton-Witt JA, et al. (2015) Effect of attachment site on stability of cleavable antibody drug conjugates. Bioconjugate Chemistry. 26: 650-9
Farias SE, Strop P, Delaria K, et al. (2014) Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugates. Bioconjugate Chemistry. 25: 240-50
Strop P, Liu SH, Dorywalska M, et al. (2013) Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chemistry & Biology. 20: 161-7
Marshall RA, Dorywalska M, Puglisi JD. (2008) Irreversible chemical steps control intersubunit dynamics during translation. Proceedings of the National Academy of Sciences of the United States of America. 105: 15364-9
Marshall RA, Aitken CE, Dorywalska M, et al. (2008) Translation at the single-molecule level. Annual Review of Biochemistry. 77: 177-203
Uemura S, Dorywalska M, Lee TH, et al. (2007) Peptide bond formation destabilizes Shine-Dalgarno interaction on the ribosome. Nature. 446: 454-7
Dorywalska M, Blanchard SC, Gonzalez RL, et al. (2005) Site-specific labeling of the ribosome for single-molecule spectroscopy. Nucleic Acids Research. 33: 182-9
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