Charles M. Keyari, Ph.D.

Affiliations: 
2007 University of Arizona, Tucson, AZ 
Area:
Organic Synthesis
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"Charles Keyari"
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Robin L. Polt grad student 2007 University of Arizona
 (Glycosylating enkephalins: Design, glycosylation using sugar acetates in the preparation of glycosyl amino acids for glycopeptide syntheses, binding at the opioid receptors and analgesic effects.)
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Publications

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Newell JL, Keyari CM, McDaniel SW, et al. (2014) Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system Xc(-) cystine/glutamate exchanger. Neurochemistry International. 73: 132-8
Keyari CM, Kearns AK, Duncan NS, et al. (2013) Synthesis of new quinolinequinone derivatives and preliminary exploration of their cytotoxic properties. Journal of Medicinal Chemistry. 56: 3806-19
Keyari CM, Polt R, Nichol GS. (2010) (S)-Methyl 2-{(S)-2-[bis-(4-meth-oxy-phen-yl)methyl-idene-amino]-3-hy-droxy-propanamido}-3-methyl-butano-ate. Acta Crystallographica. Section E, Structure Reports Online. 67: o13-4
Keyari CM, Polt R. (2010) Serine and threonine Schiff base esters react with β-anomeric peracetates in the presence of BF3·Et2O to produce β-glycosides Journal of Carbohydrate Chemistry. 29: 181-206
Keyari CM, Knapp BI, Bidlack JM, et al. (2009) Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice. Advances in Experimental Medicine and Biology. 611: 495-6
Lowery JJ, Yeomans L, Keyari CM, et al. (2007) Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7
Polt R, Dhanasekaran M, Keyari CM. (2005) Glycosylated neuropeptides: a new vista for neuropsychopharmacology? Medicinal Research Reviews. 25: 557-85
Dhanasekaran M, Palian MM, Alves I, et al. (2005) Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48
Egleton RD, Bilsky EJ, Tollin G, et al. (2005) Biousian glycopeptides penetrate the blood-brain barrier Tetrahedron Asymmetry. 16: 65-75
Elmagbari NO, Egleton RD, Palian MM, et al. (2004) Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7
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