Dominic J. Yee, Ph.D.

2006 Columbia University, New York, NY 
organic synthesis
"Dominic Yee"
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Dalibor Sames grad student 2006 Columbia
 (New fluorogenic reporters for imaging the activities of redox enzymes in living cells.)
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Rodriguez PC, Yee DJ, Sames D. (2010) Expanding the use of fluorogenic enzyme reporter substrates to imaging metabolic flux changes: the activity measurement of 5α-steroid reductase in intact mammalian cells. Acs Chemical Biology. 5: 1045-52
Halim M, Yee DJ, Sames D. (2008) Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng. Journal of the American Chemical Society. 130: 14123-8
Jockusch S, Zheng Q, He GS, et al. (2007) Two-photon excitation of fluorogenic probes for redox metabolism: Dramatic enhancement of optical contrast ratio by two-photon excitation Journal of Physical Chemistry C. 111: 8872-8877
Yee DJ, Balsanek V, Bauman DR, et al. (2006) Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 13304-9
Chen G, Yee DJ, Gubernator NG, et al. (2005) Design of optical switches as metabolic indicators: new fluorogenic probes for monoamine oxidases (MAO A and B). Journal of the American Chemical Society. 127: 4544-5
Yee DJ, Balsanek V, Sames D. (2004) New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3 alpha-hydroxysteroid dehydrogenases. Journal of the American Chemical Society. 126: 2282-3
Chen G, Heim A, Riether D, et al. (2003) Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling. Journal of the American Chemical Society. 125: 8130-3
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