Patricia M. Legler, Ph.D.

Affiliations: 
2002 Johns Hopkins University, Baltimore, MD 
Area:
Mechanisms of enzyme action; enzymes of DNA and ATP hydrolysis; isomerases; nuclear magnetic resonance and electron spin resonance
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"Patricia Legler"
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Albert S. Mildvan grad student 2002 Johns Hopkins
 (Kinetic, magnetic resonance, and mutational studies of the mechanism of GDP -mannose mannosyl hydrolase, an unusual Nudix enzyme.)
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Publications

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Hu X, Compton JR, Leary DH, et al. (2016) Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. Biochemistry
Olson MA, Legler PM, Goldman ER. (2016) Comparison of Replica Exchange Simulations of a Kinetically Trapped Protein Conformational State and Its Native Form. The Journal of Physical Chemistry. B
Olson MA, Zabetakis D, Legler PM, et al. (2015) Can template-based protein models guide the design of sequence fitness for enhanced thermal stability of single domain antibodies? Protein Engineering, Design & Selection : Peds. 28: 395-402
Legler PM, Soojhawon I, Millard CB. (2015) A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime. Acta Crystallographica. Section D, Biological Crystallography. 71: 1788-98
Wang Z, Robertson KL, Liu C, et al. (2015) A novel Vibrio beta-glucosidase (LamN) that hydrolyzes the algal storage polysaccharide laminarin. Fems Microbiology Ecology
Zabetakis D, Olson MA, Anderson GP, et al. (2014) Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody. Plos One. 9: e115405
Khavrutskii IV, Legler PM, Friedlander AM, et al. (2014) A reaction path study of the catalysis and inhibition of the Bacillus anthracis CapD γ-glutamyl transpeptidase. Biochemistry. 53: 6954-67
George J, Compton JR, Leary DH, et al. (2014) Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins. 82: 3101-16
Hu X, Legler PM, Southall N, et al. (2014) Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening. Journal of Computer-Aided Molecular Design. 28: 765-78
Turner KB, Zabetakis D, Legler P, et al. (2014) Isolation and epitope mapping of staphylococcal enterotoxin B single-domain antibodies. Sensors (Basel, Switzerland). 14: 10846-63
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