Chu-Young Kim, Ph.D.

Affiliations: 
2001 University of Pennsylvania, Philadelphia, PA, United States 
Area:
structure-mechanism of hydrolytic metalloenzymes
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"Chu-Young Kim"
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David W. Christianson grad student 2001 Penn
 (Structural investigation of inhibitor binding to carbonic anhydrases II and IV using crystallographic and computational methods.)
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Publications

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Wong FT, Hotta K, Chen X, et al. (2015) Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis. Journal of the American Chemical Society. 137: 86-9
Hotta K, Keegan RM, Ranganathan S, et al. (2014) Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis. Angewandte Chemie (International Ed. in English). 53: 824-8
Unudurthi SD, Hotta K, Kim CY. (2013) Engineering the polyproline II propensity of a class II major histocompatibility complex ligand peptide. Acs Chemical Biology. 8: 2383-7
Hotta K, Chen X, Paton RS, et al. (2012) Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature. 483: 355-8
Tollefsen S, Hotta K, Chen X, et al. (2012) Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule. The Journal of Biological Chemistry. 287: 13611-9
Bodd M, Kim CY, Lundin KE, et al. (2012) T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease. Gastroenterology. 142: 552-61
Hotta K, Kim CY, Fox DT, et al. (2010) Siderophore-mediated iron acquisition in Bacillus anthracis and related strains. Microbiology (Reading, England). 156: 1918-25
Fallang LE, Bergseng E, Hotta K, et al. (2009) Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation. Nature Immunology. 10: 1096-101
Fox DT, Hotta K, Kim CY, et al. (2008) The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase. Biochemistry. 47: 12251-3
Koppisch AT, Hotta K, Fox DT, et al. (2008) Biosynthesis of the 3,4-dihydroxybenzoate moieties of petrobactin by Bacillus anthracis. The Journal of Organic Chemistry. 73: 5759-65
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