L. S. Vedula, Ph.D.

Affiliations: 
2007 University of Pennsylvania, Philadelphia, PA, United States 
Area:
structure-mechanism of hydrolytic metalloenzymes
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"L. Vedula"
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David W. Christianson grad student 2007 Penn
 (Sesquiterpene biosynthesis.)
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Publications

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Harris GG, Lombardi PM, Pemberton TA, et al. (2015) Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry
Oakley S, Vedula LS, Bu W, et al. (2012) Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis. Plos One. 7: e32070
Vedula LS, Brannigan G, Economou NJ, et al. (2009) A unitary anesthetic binding site at high resolution. The Journal of Biological Chemistry. 284: 24176-84
Vedula LS, Jiang J, Zakharian T, et al. (2008) Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif. Archives of Biochemistry and Biophysics. 469: 184-94
Vedula LS, Zhao Y, Coates RM, et al. (2007) Exploring biosynthetic diversity with trichodiene synthase. Archives of Biochemistry and Biophysics. 466: 260-6
Vedula LS, Cane DE, Christianson DW. (2005) Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase. Biochemistry. 44: 12719-27
Vedula LS, Rynkiewicz MJ, Pyun HJ, et al. (2005) Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. Biochemistry. 44: 6153-63
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