Heather A. Gennadios, Ph.D.

2008 University of Pennsylvania, Philadelphia, PA, United States 
structure-mechanism of hydrolytic metalloenzymes
"Heather Gennadios"
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David W. Christianson grad student 2008 Penn
 (Structural studies of a zinc -dependent deacetylase and a sesquiterpene cyclase.)
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Gennadios HA, Gonzalez V, Di Costanzo L, et al. (2009) Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis. Biochemistry. 48: 6175-83
Dowling DP, Di Costanzo L, Gennadios HA, et al. (2008) Evolution of the arginase fold and functional diversity. Cellular and Molecular Life Sciences : Cmls. 65: 2039-55
Shin H, Gennadios HA, Whittington DA, et al. (2007) Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC. Bioorganic & Medicinal Chemistry. 15: 2617-23
Gennadios HA, Christianson DW. (2006) Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding. Biochemistry. 45: 15216-23
Gennadios HA, Whittington DA, Li X, et al. (2006) Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase. Biochemistry. 45: 7940-8
Hernick M, Gennadios HA, Whittington DA, et al. (2005) UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism. The Journal of Biological Chemistry. 280: 16969-78
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