Patrick M. Lombardi, Ph.D.
Affiliations: | Johns Hopkins University School of Medicine, Baltimore, MD, United States |
Area:
structure-mechanism of hydrolytic metalloenzymesGoogle:
"Patrick Lombardi"Mean distance: 8.61 | S | N | B | C | P |
Parents
Sign in to add mentor| David W. Christianson | grad student | 2006-2011 | Penn | |
| (Structural studies of acetylpolyamine amidohydrolase.) | ||||
| Cynthia Wolberger | post-doc | 2012- | Johns Hopkins Medical School | |
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Publications
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| Lombardi PM, Haile S, Rusanov T, et al. (2021) The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin. The Journal of Biological Chemistry. 101545 |
| Brickner JR, Soll JM, Lombardi PM, et al. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. 551: 389-393 |
| Lombardi PM, Matunis MJ, Wolberger C. (2017) RAP80, ubiquitin and SUMO in the DNA damage response. Journal of Molecular Medicine (Berlin, Germany) |
| Harris GG, Lombardi PM, Pemberton TA, et al. (2015) Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry |
| Wiener R, DiBello AT, Lombardi PM, et al. (2013) E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nature Structural & Molecular Biology. 20: 1033-9 |
| Deardorff MA, Bando M, Nakato R, et al. (2012) HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature. 489: 313-7 |
| Ilies M, Dowling DP, Lombardi PM, et al. (2011) Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorganic & Medicinal Chemistry Letters. 21: 5854-8 |
| Lombardi PM, Cole KE, Dowling DP, et al. (2011) Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes. Current Opinion in Structural Biology. 21: 735-43 |
| Lombardi PM, Angell HD, Whittington DA, et al. (2011) Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases. Biochemistry. 50: 1808-17 |