Patrick M. Lombardi, Ph.D.

Affiliations: 
Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Area:
structure-mechanism of hydrolytic metalloenzymes
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Parents

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David W. Christianson grad student 2006-2011 Penn
 (Structural studies of acetylpolyamine amidohydrolase.)
Cynthia Wolberger post-doc 2012- Johns Hopkins Medical School
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Publications

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Brickner JR, Soll JM, Lombardi PM, et al. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. 551: 389-393
Lombardi PM, Matunis MJ, Wolberger C. (2017) RAP80, ubiquitin and SUMO in the DNA damage response. Journal of Molecular Medicine (Berlin, Germany)
Harris GG, Lombardi PM, Pemberton TA, et al. (2015) Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry
Wiener R, DiBello AT, Lombardi PM, et al. (2013) E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nature Structural & Molecular Biology. 20: 1033-9
Deardorff MA, Bando M, Nakato R, et al. (2012) HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature. 489: 313-7
Ilies M, Dowling DP, Lombardi PM, et al. (2011) Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorganic & Medicinal Chemistry Letters. 21: 5854-8
Lombardi PM, Cole KE, Dowling DP, et al. (2011) Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes. Current Opinion in Structural Biology. 21: 735-43
Lombardi PM, Angell HD, Whittington DA, et al. (2011) Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases. Biochemistry. 50: 1808-17
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