Gregory R. Hoffman, Ph.D.

Affiliations: 
2002 Cornell University, Ithaca, NY, United States 
Area:
Signal Transduction Mechanisms
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"Gregory Hoffman"
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Parents

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Richard A. Cerione grad student 2002 Cornell
 (The structural basis of Cdc42-mediated signal transduction.)
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Publications

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DeJesus R, Moretti F, McAllister G, et al. (2016) Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62. Elife. 5
Mavrakis KJ, McDonald ER, Schlabach MR, et al. (2016) Disordered methionine metabolism in MTAP/CDKN2A deleted cancers leads to dependence on PRMT5. Science (New York, N.Y.)
Eng CH, Wang Z, Tkach D, et al. (2015) Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy. Proceedings of the National Academy of Sciences of the United States of America
Lantermann AB, Chen D, McCutcheon KJ, et al. (2015) Inhibition of casein kinase 1 alpha prevents acquired drug resistance to erlotinib in EGFR-mutant non-small cell lung cancer. Cancer Research
Li J, Csibi A, Yang S, et al. (2015) Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E21-9
Hoffman GR, Rahal R, Buxton F, et al. (2014) Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 3128-33
Kim SG, Hoffman GR, Poulogiannis G, et al. (2013) Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell. 49: 172-85
Yu Y, Yoon SO, Poulogiannis G, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (New York, N.Y.). 332: 1322-6
Lipinski MM, Hoffman G, Ng A, et al. (2010) A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental Cell. 18: 1041-52
Hoffman GR, Moerke NJ, Hsia M, et al. (2010) A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay and Drug Development Technologies. 8: 186-99
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