Scott B. Ficarro, Ph.D.

Affiliations: 
2002 University of Virginia, Charlottesville, VA 
Area:
Analytical Biochemistry
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"Scott Ficarro"
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Donald F. Hunt grad student 2002 UVA
 (Enrichment and analysis of phosphorylated peptides by immobilized metal affinity chromatography and nanoflow -HPLC /microelectrospray ionization /tandem mass spectrometry.)
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Publications

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Vohhodina J, Goehring LJ, Liu B, et al. (2021) BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Nature Communications. 12: 3542
Dubiella C, Pinch BJ, Koikawa K, et al. (2021) Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nature Chemical Biology
Jiang B, Jiang J, Kaltheuner IH, et al. (2021) Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. European Journal of Medicinal Chemistry. 221: 113481
Hatcher JM, Yang G, Wang L, et al. (2020) Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma. Acs Medicinal Chemistry Letters. 11: 2238-2243
Jiang J, Jiang B, He Z, et al. (2020) Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chemical Biology
Fu A, Alvarez-Perez JC, Avizonis D, et al. (2020) Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation. Nature Metabolism. 2: 432-446
Teng M, Ficarro SB, Yoon H, et al. (2020) Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. Acs Medicinal Chemistry Letters. 11: 1269-1273
Liu Y, Hao M, Leggett A, et al. (2020) Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. Journal of Medicinal Chemistry
Pinch BJ, Doctor ZM, Nabet B, et al. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nature Chemical Biology
Manz TD, Sivakumaren SC, Ferguson FM, et al. (2020) Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Journal of Medicinal Chemistry
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