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Alexander J. Ruthenburg, Ph.D.

2005 Harvard University, Cambridge, MA, United States 
 2010- Molecular Genetics and Cell Biology University of Chicago, Chicago, IL 
chromatin, biochemistry, chemical biology, structure
"Alexander Ruthenburg"

Mean distance: 7.88


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Gregory L. Verdine grad student 2005 Harvard
 (Type II topoisomerase-DNA interactions: Structure, mechanism, and covalent trapping.)
C. David Allis post-doc 2006-2010 Rockefeller


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Johnathon M Hall grad student 2016- Chicago
Zhonglei Chen grad student 2014 Chicago
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Hattori T, Lai D, Dementieva IS, et al. (2016) Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Proceedings of the National Academy of Sciences of the United States of America
Werner MS, Ruthenburg AJ. (2015) Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes. Cell Reports. 12: 1089-98
Grzybowski AT, Chen Z, Ruthenburg AJ. (2015) Calibrating ChIP-Seq with Nucleosomal Internal Standards to Measure Histone Modification Density Genome Wide. Molecular Cell. 58: 886-99
Rothbart SB, Dickson BM, Raab JR, et al. (2015) An Interactive Database for the Assessment of Histone Antibody Specificity Molecular Cell. 59: 502-511
Chen Z, Grzybowski AT, Ruthenburg AJ. (2014) Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks. Chembiochem : a European Journal of Chemical Biology. 15: 2071-5
Hattori T, Taft JM, Swist KM, et al. (2013) Recombinant antibodies to histone post-translational modifications. Nature Methods. 10: 992-5
Malecek K, Ruthenburg A. (2012) Validation of histone-binding partners by peptide pull-downs and isothermal titration calorimetry Methods in Enzymology. 512: 187-220
Mohrig JR, Beyer BG, Fleischhacker AS, et al. (2012) Does activation of the anti proton, rather than concertedness, determine the stereochemistry of base-catalyzed 1,2-elimination reactions? Anti stereospecificity in E1cB eliminations of β-3-trifluoromethylphenoxy esters, thioesters, and ketones. The Journal of Organic Chemistry. 77: 2819-28
Werner M, Ruthenburg AJ. (2011) The United States of histone ubiquitylation and methylation. Molecular Cell. 43: 5-7
Ruthenburg AJ, Li H, Milne TA, et al. (2011) Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 145: 692-706
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