Fei You, Ph.D.

Affiliations: 
2003 Brown University, Providence, RI 
Area:
Natural product total synthesis
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"Fei You"
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Kathlyn A. Parker grad student 2003 Brown
 (Part 1. Synthetic studies toward total synthesis of deacetylravidomycins. Part 2. Design and synthesis of bifunctional inhibitors for HIV-1 reverse transcriptase.)
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Publications

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Vlahov IR, Qi L, Santhapuram HKR, et al. (2020) Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate. Bioorganic & Medicinal Chemistry Letters. 126987
Rangasamy L, Chelvam V, Kanduluru AK, et al. (2018) New mechanism for release of endosomal contents: osmotic lysis via nigericin-mediated K/Hexchange. Bioconjugate Chemistry
Vlahov IR, Qi L, Kleindl PJ, et al. (2017) Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates. Bioconjugate Chemistry
You F, Jiang L, Zhang B, et al. (2016) Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells. Science China. Life Sciences
Vlahov I, You F, Kleindl P, et al. (2016) Abstract 4735: Designing novel warheads for targeted therapies: SAR and efficient strategies for the synthesis of analogues of tubulysin Cancer Research. 76: 4735-4735
Lu Y, Parker N, Kleindl PJ, et al. (2015) Anti-Inflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus. Molecular Medicine (Cambridge, Mass.)
Leamon CP, Reddy JA, Vlahov IR, et al. (2015) Abstract 4488: Folate receptor targeted therapy using small molecule drug conjugates constructed with high affinity antifolate ligands Cancer Research. 75: 4488-4488
Vlahov IR, You F, Klein HF, et al. (2015) Abstract 4393: Design and synthesis of novel conjugates for targeting the folate receptor: Exploiting cytotoxic GARFTase inhibitors for delivering additional chemotherapeutic payloads to cancer cells Cancer Research. 75: 4393-4393
Leamon CP, Vlahov IR, Reddy JA, et al. (2014) Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship. Bioconjugate Chemistry. 25: 560-8
Wang K, Hahn S, Santhapuram H, et al. (2014) Abstract 4462: Structure-activity relationship studies for PSMA-targeted tubulysin conjugates Cancer Research. 74: 4462-4462
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