Louise K. Charkoudian, Ph.D.

Affiliations: 
2008 Duke University, Durham, NC 
Area:
metal ion coordination in biological systems
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"Louise Charkoudian"
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Parents

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Katherine J. Franz grad student 2008 Duke
 (Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress.)
Chaitan Khosla post-doc Stanford
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Publications

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Li K, Cho YI, Tran MA, et al. (2025) Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro. Acs Chemical Biology
McBride CM, Miller EL, Charkoudian LK. (2023) An updated catalogue of diverse type II polyketide synthase biosynthetic gene clusters captured from large-scale nucleotide databases. Microbial Genomics. 9
Hamrick GS, Londergan CH, Charkoudian LK. (2022) Heterologous Expression, Purification, and Characterization of Type II Polyketide Synthase Acyl Carrier Proteins. Methods in Molecular Biology (Clifton, N.J.). 2489: 239-267
Cho YI, Armstrong CL, Sulpizio A, et al. (2022) Engineered Chimeras Unveil Swappable Modular Features of Fatty Acid and Polyketide Synthase Acyl Carrier Proteins. Biochemistry
Sulpizio A, Crawford CEW, Koweek RS, et al. (2021) Probing the structure and function of acyl carrier proteins to unlock the strategic redesign of type II polyketide biosynthetic pathways. The Journal of Biological Chemistry. 100328
Klein JG, Wu Y, Kokona B, et al. (2020) Widening the bottleneck: Heterologous expression, purification, and characterization of the Ktedonobacter racemifer minimal type II polyketide synthase in Escherichia coli. Bioorganic & Medicinal Chemistry. 28: 115686
Klein JG, Kokona B, Charkoudian LK. (2020) Heterologous Expression and Characterization of Ancient Orphaned Type II Polyketide Synthase Enzymes The Faseb Journal. 34: 1-1
Armstrong C, Kokona B, Charkoudian LK. (2020) Constructing Combinatorial Synthases Using Acyl Carrier Protein Chimeras The Faseb Journal. 34: 1-1
Acheampong KK, Kokona B, Braun GA, et al. (2019) Colorimetric Assay Reports on Acyl Carrier Protein Interactions. Scientific Reports. 9: 15589
Epstein SC, Huff AR, Winesett ES, et al. (2019) Tracking carrier protein motions with Raman spectroscopy. Nature Communications. 10: 2227
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