Nathan J. Wymer, Ph.D.

Affiliations: 
2002 Duke University, Durham, NC 
Area:
biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide
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"Nathan Wymer"
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Eric J. Toone grad student 2002 Duke
 (Exploring structure-function of the KDPG aldolase with site-directed mutagenesis and directed evolution.)
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Publications

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Badland M, Burns MP, Carroll RJ, et al. (2011) Application of biocatalysis towards asymmetric reduction and hydrolytic desymmetrisation in the synthesis of a β-3 receptor agonist Green Chemistry. 13: 2888-2894
Woodyer RD, Wymer NJ, Racine FM, et al. (2008) Efficient production of L-ribose with a recombinant Escherichia coli biocatalyst. Applied and Environmental Microbiology. 74: 2967-75
Fullerton SW, Griffiths JS, Merkel AB, et al. (2006) Mechanism of the Class I KDPG aldolase. Bioorganic & Medicinal Chemistry. 14: 3002-10
Griffiths JS, Wymer NJ, Njolito E, et al. (2002) Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase. Bioorganic & Medicinal Chemistry. 10: 545-50
Wymer N, Buchanan LV, Henderson D, et al. (2001) Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. Structure (London, England : 1993). 9: 1-9
Wymer N, Toone EJ. (2000) Enzyme-catalyzed synthesis of carbohydrates. Current Opinion in Chemical Biology. 4: 110-9
Gerasimov OV, Wymer N, Miller D, et al. (1999) Intracellular Delivery of Liposomal Contents Using pH- and Light-Activated Plasmenyl-Type Liposomes Acs Symposium Series. 728: 164-178
Wymer NJ, Gerasimov OV, Thompson DH. (1998) Cascade liposomal triggering: light-induced Ca2+ release from diplasmenylcholine liposomes triggers PLA2-catalyzed hydrolysis and contents leakage from DPPC liposomes. Bioconjugate Chemistry. 9: 305-8
Toone EJ, Simon ES, Bednarski MD, et al. (1989) Enzyme-catalyzed synthesis of carbohydrates Tetrahedron. 45: 5365-5422
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