David M. Gooden, Ph.D.

2006 Duke University, Durham, NC 
biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide
"David Gooden"
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Eric J. Toone grad student 2006 Duke
 (Synthesis and physical organic chemistry of C-nitroso compounds: A study of C-nitroso ketones as selective nitrosonium donors.)
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Zhao J, Cochrane CS, Najeeb J, et al. (2023) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Science Translational Medicine. 15: eadf5668
Buhimschi AD, Gooden DM, Jing H, et al. (2020) Psoralen Derivatives with Enhanced Potency. Photochemistry and Photobiology
York B, Li F, Lin F, et al. (2017) Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Scientific Reports. 7: 11793
Foster MW, Yang Z, Gooden DM, et al. (2017) Correction to "Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition". Journal of Proteome Research
Xia W, Gooden D, Liu L, et al. (2014) Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. Plos One. 9: e88983
Sinclair S, Bhattacharyya J, Little D, et al. (2013) Pharmacokinetics of a thermally responsive curcumin conjugate for local antagonism of neuroinflammation in disc herniation Osteoarthritis and Cartilage. 21: S292-S293
Wang J, Mook RA, Lu J, et al. (2012) Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling. Bioorganic & Medicinal Chemistry. 20: 6751-7
Gooden DM, Chakrapani H, Toone EJ. (2005) C-nitroso compounds: synthesis, physicochemical properties and biological activities. Current Topics in Medicinal Chemistry. 5: 687-705
Winter-Vann AM, Baron RA, Wong W, et al. (2005) A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 4336-41
Christensen T, Gooden DM, Kung JE, et al. (2003) Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction. Journal of the American Chemical Society. 125: 7357-66
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