David A. Carlson, Ph.D.

Affiliations: 
2010 Chemistry Duke University, Durham, NC 
Area:
biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide
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"David Carlson"
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Parents

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Eric J. Toone grad student 2010 Duke
 (New approaches to studying non-covalent molecular interactions in nano-confined environments.)
Timothy Arthur James Haystead post-doc 2010- Duke
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Publications

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Scarneo SA, Hughes PF, Yang KW, et al. (2019) A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. The Journal of Biological Chemistry
Liao KC, Sandall CF, Carlson DA, et al. (2019) Application of immobilized ATP to the study of NLRP inflammasomes. Archives of Biochemistry and Biophysics
Scarneo SA, Mansourati A, Eibschutz LS, et al. (2018) Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. Scientific Reports. 8: 17058
Carlson DA, Singer MR, Sutherland C, et al. (2018) Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chemical Biology
Bellaye PS, Shimbori C, Yanagihara T, et al. (2018) Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. The European Respiratory Journal. 51
Totzke J, Gurbani D, Raphemot R, et al. (2017) Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. Cell Chemical Biology. 24: 1029-1039.e7
Alwarawrah Y, Hughes P, Loiselle D, et al. (2016) Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chemical Biology
MacDonald JA, Sutherland C, Carlson DA, et al. (2015) A Small Molecule Pyrazolo[3,4-d]pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Molecular Pharmacology
Howe MK, Bodoor K, Carlson DA, et al. (2014) Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chemistry & Biology. 21: 1648-59
Carlson DA, Franke AS, Weitzel DH, et al. (2013) Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. Acs Chemical Biology. 8: 2715-23
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