John M. Knapp, Ph.D.
Affiliations: | 2012 | Chemistry | University of California, Davis, Davis, CA |
Area:
Combinatorial chemistry, heterocyclic chemistry, understanding reaction mechanisms, solid phase organic synthesis, polymer chemistry, organic synthesis, reaction methodology, and structure elucidationGoogle:
"John Knapp"Mean distance: 8.92 | S | N | B | C | P |
Parents
Sign in to add mentor| Mark Joseph Kurth | grad student | 2012 | UC Davis | |
| (Identification & Synthesis of Active Compounds Against Cystic Fibrosis and Multicomponent Methodology Development.) | ||||
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Publications
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| Ye L, Dickerson T, Kaur H, et al. (2013) Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3. Bioorganic & Medicinal Chemistry Letters. 23: 340-5 |
| Knapp JM, Zhu JS, Tantillo DJ, et al. (2012) Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Angewandte Chemie (International Ed. in English). 51: 10588-91 |
| Knapp JM, Wood AB, Phuan PW, et al. (2012) Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein. Journal of Medicinal Chemistry. 55: 1242-51 |
| Knapp JM, Zhu JS, Wood AB, et al. (2012) Expedient synthesis of a 72-membered isoxazolino-β-ketoamide library by a 2·3-component reaction. Acs Combinatorial Science. 14: 85-8 |
| Knapp JM, Fettinger JC, Kurth MJ. (2011) Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Organic Letters. 13: 4732-5 |
| Phuan PW, Yang B, Knapp JM, et al. (2011) Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis. Molecular Pharmacology. 80: 683-93 |
| Ye L, Knapp JM, Sangwung P, et al. (2010) Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. Journal of Medicinal Chemistry. 53: 3772-81 |