Bethany L. Kormos, Ph.D.

Affiliations: 
2004 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Theoretical Chemistry, Molecular Modeling, Computational Chemistry, Structure, Reactivity, and Mechanism
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"Bethany Kormos"
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SNBCP

Parents

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Christopher J. Cramer grad student 2004 UMN
 (The study of liquid solution and solid phase systems: I. Reactions and thermodynamics of alkyl halides. II. Structures and energetics of group 13-15 compounds.)
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Publications

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Wang Q, Amato SP, Rubitski DM, et al. (2015) Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK. The Journal of Pharmacology and Experimental Therapeutics
Henderson JL, Kormos BL, Hayward MM, et al. (2015) Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Journal of Medicinal Chemistry. 58: 419-32
Galatsis P, Henderson JL, Kormos BL, et al. (2014) Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold. Bioorganic & Medicinal Chemistry Letters. 24: 4132-40
Galatsis P, Henderson J, Kormos BL, et al. (2014) Development of LRRK2 kinase inhibitors for parkinson's disease Annual Reports in Medicinal Chemistry. 49: 43-58
Tuttle JB, Kormos BL. (2014) The use of PDE10A AND PDE9 inhibitors for treating schizophrenia Topics in Medicinal Chemistry. 13: 255-316
Am Ende CW, Kormos BL, Humphrey JM. (2014) The State of the Art in Selective PDE2A Inhibitor Design Phosphodiesterases and Their Inhibitors. 61: 83-104
Wager TT, Kormos BL, Brady JT, et al. (2013) Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies. Journal of Medicinal Chemistry. 56: 9771-9
Stepan AF, Subramanyam C, Efremov IV, et al. (2012) Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor. Journal of Medicinal Chemistry. 55: 3414-24
Kormos BL, Pieniazek SN, Beveridge DL, et al. (2011) U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations. Biopolymers. 95: 591-606
Anunciado D, Agumeh M, Kormos BL, et al. (2008) Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements. The Journal of Physical Chemistry. B. 112: 6122-30
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