Jonathan K. Dozier, Ph.D.

Affiliations: 
2014 Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
protein engineering, protein prenylation and cellular patterning
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Mark D. Distefano grad student 2014 UMN
 (Studies and applications of protein prenylation using isoprenoid analogues and site-directed mutagenesis.)
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Publications

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Mohammed I, Hampton SE, Ashall L, et al. (2015) 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorganic & Medicinal Chemistry
Dozier JK, Distefano MD. (2015) Site-Specific PEGylation of Therapeutic Proteins. International Journal of Molecular Sciences. 16: 25831-64
Dozier JK, Khatwani SL, Wollack JW, et al. (2014) Engineering protein farnesyltransferase for enzymatic protein labeling applications. Bioconjugate Chemistry. 25: 1203-12
Wollack JW, Monson BJ, Dozier JK, et al. (2014) Site-specific labeling of proteins and peptides with trans-cyclooctene containing handles capable of tetrazine ligation. Chemical Biology & Drug Design. 84: 140-7
Wang YC, Dozier JK, Beese LS, et al. (2014) Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. Acs Chemical Biology. 9: 1726-35
Tolstyka ZP, Richardson W, Bat E, et al. (2013) Chemoselective immobilization of proteins by microcontact printing and bio-orthogonal click reactions. Chembiochem : a European Journal of Chemical Biology. 14: 2464-71
Mahmoodi MM, Rashidian M, Dozier JK, et al. (2013) Chemoenzymatic site-specific reversible immobilization and labeling of proteins from crude cellular extract without prior purification using oxime and hydrazine ligation. Current Protocols in Chemical Biology. 5: 89-109
Rashidian M, Dozier JK, Distefano MD. (2013) Enzymatic labeling of proteins: techniques and approaches. Bioconjugate Chemistry. 24: 1277-94
Rashidian M, Mahmoodi MM, Shah R, et al. (2013) A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation. Bioconjugate Chemistry. 24: 333-42
Dozier JK, Distefano MD. (2012) An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases. Analytical Biochemistry. 421: 158-63
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