Rachel S. Signarvic, Ph.D.
Affiliations: | 2006 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Organic Chemistry, Chemical Biology, De Novo Protein DesignGoogle:
"Rachel Signarvic"Mean distance: 8.51 | S | N | B | C | P |
Parents
Sign in to add mentor| William F. DeGrado | grad student | 2006 | Penn | |
| (The de novo design of molecular switches: Manipulation of secondary structure to modulate conformational stability.) | ||||
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Publications
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| Ma P, Cierniewska A, Signarvic R, et al. (2012) A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 119: 1935-45 |
| Signarvic RS, Cierniewska A, Stalker TJ, et al. (2010) RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 116: 6092-100 |
| Ma P, Cierniewska A, Signarvic R, et al. (2010) Discovery of a New Signaling Complex Based on Spinophilin That Regulates Platelet Activation In Vitro and In Vivo Blood. 116: 161-161 |
| Signarvic RS, Degrado WF. (2009) Metal-binding dependent disruption of membranes by designed helices. Journal of the American Chemical Society. 131: 3377-84 |
| Tang J, Signarvic RS, DeGrado WF, et al. (2007) Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers. Biochemistry. 46: 13856-63 |
| Signarvic RS, DeGrado WF. (2003) De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. Journal of Molecular Biology. 334: 1-12 |