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Daniel R. Wahl, Ph.D.

Affiliations: 
2012 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
anti-DNA autoantibody structure and function, and the identification of novel molecular targets and small molecules for the treatment of autoimmune diseases and cancer
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Parents

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Gary D. Glick grad student 2012 University of Michigan
 (Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation.)

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Publications

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Bell HN, Huber AK, Singhal R, et al. (2022) Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer. Cell Metabolism
Werner CK, Nna UJ, Sun H, et al. (2020) Expression of the of the androgen receptor governs radiation resistance in a subset of glioblastomas vulnerable to anti-androgen therapy. Molecular Cancer Therapeutics
Chung C, Sweha SR, Pratt D, et al. (2020) Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas. Cancer Cell
Zhou W, Yao Y, Scott AJ, et al. (2020) Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nature Communications. 11: 3811
Michmerhuizen AR, Chandler B, Olsen E, et al. (2020) Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells. Frontiers in Endocrinology. 11: 35
Nelson BS, Lin L, Kremer DM, et al. (2020) Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer & Metabolism. 8: 1
Lang X, Green MD, Wang W, et al. (2019) Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discovery
Zhou W, Wahl DR. (2019) Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance. Cancers. 11
Zhang Q, Green MD, Lang X, et al. (2019) Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy. Cancer Research
Lowenstein PR, Orringer DA, Sagher O, et al. (2019) First-in-human phase I trial of the combination of two adenoviral vectors expressing HSV1-TK and FLT3L for the treatment of newly diagnosed resectable malignant glioma: Initial results from the therapeutic reprogramming of the brain immune system. Journal of Clinical Oncology. 37: 2019-2019
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