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Sarah E. McDowell, Ph.D.

Affiliations: 
2008 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
structure-function relationships in non-coding (nc)RNAs using single molecule tools and then utilize them for biomedical, bioanalytical and nanotechnological applications
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"Sarah McDowell"
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Nils G. Walter grad student 2008 University of Michigan
 (Structure, function, and dynamics of minimal and extended hammerhead ribozymes.)

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Publications

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Johnson-Buck AE, McDowell SE, Walter NG. (2011) Metal ions: supporting actors in the playbook of small ribozymes. Metal Ions in Life Sciences. 9: 175-96
McDowell SE, Jun JM, Walter NG. (2010) Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformations. Rna (New York, N.Y.). 16: 2414-26
McDowell SE, Spacková N, Sponer J, et al. (2007) Molecular dynamics simulations of RNA: an in silico single molecule approach. Biopolymers. 85: 169-84
Rueda D, Wick K, McDowell SE, et al. (2003) Diffusely bound Mg2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core. Biochemistry. 42: 9924-36
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