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Adalgisa Batista-Parra, Ph.D.

Affiliations: 
2002 Georgia State University, Atlanta, GA, United States 
Area:
Organic Chemistry
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"Adalgisa Batista-Parra"
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David W. Boykin grad student 2002 Georgia State
 (Synthesis of analogs of 5-[2-(5-amidinobenzimidazoyl)]-2-(4-amidinophenyl)furan hydrochloride to test a DNA minor groove dimer binding model.)

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Publications

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Rettig M, Germann MW, Ismail MA, et al. (2012) Microscopic rearrangement of bound minor groove binders detected by NMR. The Journal of Physical Chemistry. B. 116: 5620-7
Liu Y, Kumar A, Depauw S, et al. (2011) Water-mediated binding of agents that target the DNA minor groove. Journal of the American Chemical Society. 133: 10171-83
Hunt RA, Munde M, Kumar A, et al. (2011) Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures. Nucleic Acids Research. 39: 4265-74
Munde M, Kumar A, Nhili R, et al. (2010) DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site. Journal of Molecular Biology. 402: 847-64
Miao Y, Lee MP, Parkinson GN, et al. (2005) Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry. 44: 14701-8
Ismail MA, Batista-Parra A, Miao Y, et al. (2005) Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents. Bioorganic & Medicinal Chemistry. 13: 6718-26
Batista-Parra A, Venkitachalam S, Wilson WD, et al. (2003) Synthesis of 2-(5-amidinobenzoxazol-2-YL)-5-(4-amidino- phenyl)furan and 2-(5-amidinobenzoxazol-2-YL)-5-(4-amidinophenyl)thiphene to test a DNA minor groove dimer binding model Heterocycles. 60: 1367-1376
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