Matthew C. Hartman, Ph.D.

Affiliations: 
2002 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
design potent and specific "mechanism-based inhibitors" of selected target enzymes for use as drugs in the treatment of cancer and parasitic diseases
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Parents

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James K. Coward grad student 2002 University of Michigan
 (The synthesis of 5-fluoro glycosides and pyrophosphates and their use in mechanistic studies in carbohydrate enzymology.)
Jack W. Szostak post-doc
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Publications

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Iqbal ES, Richardson SL, Abrigo NA, et al. (2019) A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display. Chemical Communications (Cambridge, England)
Richardson SL, Dods KK, Abrigo NA, et al. (2018) In vitro genetic code reprogramming and expansion to study protein function and discover macrocyclic peptide ligands. Current Opinion in Chemical Biology. 46: 172-179
Iqbal ES, Hartman MCT. (2018) Shaping molecular diversity. Nature Chemistry. 10: 692-694
Iqbal ES, Dods KK, Hartman MCT. (2018) Ribosomal incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase. Organic & Biomolecular Chemistry
Ring CM, Iqbal ES, Hacker DE, et al. (2017) Genetic incorporation of 4-fluorohistidine into peptides enables selective affinity purification. Organic & Biomolecular Chemistry
Hacker DE, Hoinka J, Iqbal ES, et al. (2017) Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display. Acs Chemical Biology
Dcona MM, Sheldon JE, Mitra D, et al. (2016) Light induced drug release from a folic acid-drug conjugate. Bioorganic & Medicinal Chemistry Letters
Sheldon JE, Dcona MM, Lyons CE, et al. (2015) Photoswitchable anticancer activity via trans-cis isomerization of a combretastatin A-4 analog. Organic & Biomolecular Chemistry
Michael Dcona M, Yu Q, Capobianco JA, et al. (2015) Near infrared light mediated release of doxorubicin using upconversion nanoparticles. Chemical Communications (Cambridge, England). 51: 8477-9
White ER, Sun L, Ma Z, et al. (2015) Peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domain. Acs Chemical Biology. 10: 1198-208
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