Michelle R. Garnsey, Ph.D.

2012 Chemistry Duke University, Durham, NC 
"Michelle Garnsey"
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Don M. Coltart grad student 2012 Duke
 (Direct Carbon-Carbon Bond Formation via Base Mediated and Reductive Soft Enolization of Thioesters, the First Asymmetric Total Synthesis of (+)- and (-)- Clusianone, and Progress Toward the Asymmetric Total Synthesis of Brasilicardin A.)
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Davoren JE, Lee CW, Garnsey M, et al. (2016) Discovery of the potent and selective M1 PAM-agonist N-[(3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of efficacy and cholinergic side effects. Journal of Medicinal Chemistry
Garnsey MR, Uteuliyev MM, Coltart DM. (2015) Asymmetric synthesis of structural analogues of (+)-clusianone via enantioselective ACC alkylation Tetrahedron Letters. 56: 3183-3185
Garnsey MR, Matous JA, Kwiek JJ, et al. (2011) Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity. Bioorganic & Medicinal Chemistry Letters. 21: 2406-9
Garnsey MR, Lim D, Yost JM, et al. (2010) Development of a strategy for the asymmetric synthesis of polycyclic polyprenylated acylphloroglucinols via N-amino cyclic carbamate hydrazones: application to the total synthesis of (+)-clusianone. Organic Letters. 12: 5234-7
Sauer SJ, Garnsey MR, Coltart DM. (2010) Direct carbon-carbon bond formation via reductive soft enolization: a kinetically controlled syn-aldol addition of α-halo thioesters and enolizable aldehydes. Journal of the American Chemical Society. 132: 13997-9
Kohler MC, Yost JM, Garnsey MR, et al. (2010) Direct carbon-carbon bond formation via soft enolization: a biomimetic asymmetric Mannich reaction of phenylacetate thioesters. Organic Letters. 12: 3376-9
Yost JM, Garnsey MR, Kohler MC, et al. (2009) Direct carbon-carbon bond formation via soft enolization of thioesters: An operationally simple mannich addition reaction Synthesis. 56-58
Castle SA, Owuor EA, Thompson SH, et al. (2008) Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids. Eukaryotic Cell. 7: 1611-5
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