Margie T. Borra, Ph.D.

Affiliations: 
2005 University of Wisconsin, Madison, Madison, WI 
Area:
Chromatin and epigenetics
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"Margie Borra"
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John M. Denu grad student 2005 UW Madison
 (Biological roles, substrate specificity, mechanism, and regulation of the Sir2 family of NAD(+)-dependent protein deacetylases.)
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Publications

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Borra MT, Smith BC, Denu JM. (2005) Mechanism of human SIRT1 activation by resveratrol. The Journal of Biological Chemistry. 280: 17187-95
Borra MT, Langer MR, Slama JT, et al. (2004) Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry. 43: 9877-87
Kaddis J, Zurita C, Moran J, et al. (2004) Estimation of binding constants for the substrate and activator of Rhodobacter sphaeroides adenosine 5'-diphosphate-glucose pyrophosphorylase using affinity capillary electrophoresis. Analytical Biochemistry. 327: 252-60
Borra MT, Denu JM. (2004) Quantitative assays for characterization of the Sir2 family of NAD(+)-dependent deacetylases. Methods in Enzymology. 376: 171-87
North BJ, Marshall BL, Borra MT, et al. (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Molecular Cell. 11: 437-44
Borra MT, O'Neill FJ, Jackson MD, et al. (2002) Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. The Journal of Biological Chemistry. 277: 12632-41
Meyer CR, Borra M, Igarashi R, et al. (1999) Characterization of ADP-glucose pyrophosphorylase from Rhodobacter sphaeroides 2.4.1: Evidence for the involvement of arginine in allosteric regulation Archives of Biochemistry and Biophysics. 372: 179-188
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