William C. Hallows, Ph.D.

Affiliations: 
2010 University of Wisconsin, Madison, Madison, WI 
Area:
Chromatin and epigenetics
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"William Hallows"
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John M. Denu grad student 2010 UW Madison
 (Metabolic regulation by sirtuin-mediated deacetylation.)
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Publications

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Sahar S, Masubuchi S, Eckel-Mahan K, et al. (2014) Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. The Journal of Biological Chemistry. 289: 6091-7
Hallows WC, Yu W, Denu JM. (2012) Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation. The Journal of Biological Chemistry. 287: 3850-8
Hallows WC, Yu W, Smith BC, et al. (2011) Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 41: 139-49
Smith BC, Settles B, Hallows WC, et al. (2011) SIRT3 substrate specificity determined by peptide arrays and machine learning. Acs Chemical Biology. 6: 146-57
Someya S, Yu W, Hallows WC, et al. (2010) Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 143: 802-12
Ariyannur PS, Moffett JR, Madhavarao CN, et al. (2010) Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. The Journal of Comparative Neurology. 518: 2952-77
Arun P, Madhavarao CN, Moffett JR, et al. (2010) Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease. Journal of Inherited Metabolic Disease. 33: 195-210
Smith BC, Hallows WC, Denu JM. (2009) A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Analytical Biochemistry. 394: 101-9
Hallows WC, Smith BC, Lee S, et al. (2009) Ure(k)a! Sirtuins Regulate Mitochondria. Cell. 137: 404-6
Smith BC, Hallows WC, Denu JM. (2008) Mechanisms and molecular probes of sirtuins. Chemistry & Biology. 15: 1002-13
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