Chrystal M. Paulos, Ph.D.

Affiliations: 
2004 Purdue University, West Lafayette, IN, United States 
Area:
ligand-targeted imaging and therapeutic agents for the diagnosis and treatment of important human diseases
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"Chrystal Paulos"
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Philip S. Low grad student 2004 Purdue
 (From optimal dosing of folate-conjugates for the diagnosis and treatment of cancer to novel therapies in arthritis.)
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Publications

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Horvat NK, Karpovsky I, Phillips M, et al. (2024) Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy. Journal For Immunotherapy of Cancer. 12
Rangel Rivera GO, Dwyer CJ, Knochelmann HM, et al. (2023) Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity. Cancer Research
Bennion KB, Tariq M, Wyatt MM, et al. (2023) FcγRIIB expressed on CD8 T cells limits responsiveness to PD-1 checkpoint inhibition in cancer. Science Translational Medicine. 15: eadd1868
Zhang H, Passang T, Ravindranathan S, et al. (2023) The magic of small-molecule drugs during expansion in adoptive cell therapy. Frontiers in Immunology. 14: 1154566
Wyatt MM, Huff LW, Nelson MH, et al. (2023) Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy
Rangel Rivera GO, Dwyer CJ, Knochelmann HM, et al. (2023) The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner. Biorxiv : the Preprint Server For Biology
Ware MB, Phillips M, McQuinn C, et al. (2023) Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell and CXCR3-dependent manner. Jci Insight
Camargo CP, Muhuri AK, Alapan Y, et al. (2023) A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8 T cells with enhanced tumor homing to improve cell therapy. Cell Reports. 42: 112175
Riesenberg BP, Hunt EG, Tennant MD, et al. (2022) Stress-mediated attenuation of translation undermines T-cell activity in cancer. Cancer Research
Smith AS, Knochelmann HM, Wyatt MM, et al. (2022) B cells imprint adoptively transferred CD8 T cells with enhanced tumor immunity. Journal For Immunotherapy of Cancer. 10
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