Todd Holyoak, Ph.D.
Affiliations: | Biology | University of Waterloo, Waterloo, ON, Canada | |
| 2000 | University of Notre Dame, Notre Dame, IN, United States |
Area:
enzyme mechanisms, their regulation and structure and how they are interrelatedWebsite:
https://uwaterloo.ca/biology/people-profiles/todd-holyoakGoogle:
"Todd Holyoak"Mean distance: 9.94 | S | N | B | C | P |
Parents
Sign in to add mentor| Thomas L. Nowak | grad student | 2000 | Notre Dame | |
| (Kinetic, structural and genetic characterization of phosphoenolpyruvate carboxykinase.) | ||||
| Dagmar Ringe | grad student | 2003 | Brandeis | |
| Gregory A. Petsko | post-doc | 2003 | Brandeis | |
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Publications
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| McLeod MJ, Holyoak T. (2023) Biochemical, structural, and kinetic characterization of PP -dependent phosphoenolpyruvate carboxykinase from Propionibacterium freudenreichii. Proteins |
| Redzic JS, Rahkola J, Tran N, et al. (2022) A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. Communications Biology. 5: 1190 |
| Johnson TA, Holyoak T. (2012) The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry. 51: 9547-59 |
| Johnson TA, Holyoak T. (2010) Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry. 49: 5176-87 |
| Sullivan SM, Holyoak T. (2008) Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proceedings of the National Academy of Sciences of the United States of America. 105: 13829-34 |
| Sullivan SM, Holyoak T. (2007) Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. Biochemistry. 46: 10078-88 |
| Wheatley JL, Holyoak T. (2007) Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proceedings of the National Academy of Sciences of the United States of America. 104: 6626-31 |
| Holyoak T, Sullivan SM, Nowak T. (2006) Structural insights into the mechanism of PEPCK catalysis. Biochemistry. 45: 8254-63 |
| Fenn TD, Holyoak T, Stamper GF, et al. (2005) Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase. Biochemistry. 44: 5317-27 |
| Holyoak T, Nowak T. (2004) pH Dependence of the reaction catalyzed by avian mitochondrial phosphoenolpyruvate carboxykinase. Biochemistry. 43: 7054-65 |