Meredith E. Jackrel, Ph.D.

Affiliations: 
2010 Yale University, New Haven, CT 
Area:
Protein Structure, Function, and Design
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"Meredith Jackrel"
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Parents

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Lynne Joy Regan grad student 2010 Yale
 (Design of tetratricopeptide repeat proteins with novel binding specifications.)
James Shorter post-doc University of Pennsylvania Medical School (Neurotree)
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Publications

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Sprunger ML, Jackrel ME. (2024) The role of Matrin-3 in physiology and its dysregulation in disease. Biochemical Society Transactions
Lynch EM, Pittman S, Daw J, et al. (2024) Seeding competent TDP-43 persists in human patient and mouse muscle. Biorxiv : the Preprint Server For Biology
Chen S, Puri A, Bell B, et al. (2024) HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species. Nature Communications. 15: 2436
Chen S, Puri A, Bell B, et al. (2023) HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent. Research Square
Mack KL, Kim H, Barbieri EM, et al. (2023) Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell
Shrimali PC, Chen S, Das A, et al. (2023) Amyloidogenic Propensity of Self-Assembling Peptides and their Adjuvant Potential for use as DNA Vaccines. Acta Biomaterialia
Howard MK, Miller KR, Sohn BS, et al. (2023) Probing the drivers of biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases. Mbio. e0058723
Sprunger ML, Jackrel ME. (2022) Monitoring condensate dynamics in using fluorescence recovery after photobleaching. Star Protocols. 3: 101592
Sprunger ML, Lee K, Sohn BS, et al. (2022) Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology. Iscience. 25: 103900
Sprunger ML, Jackrel ME. (2021) Prion-Like Proteins in Phase Separation and Their Link to Disease. Biomolecules. 11
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